Are proton pump inhibitors really so dangerous?

Proton pump inhibitors are not antacids!

Proton pump inhibitors (PPIs) are among the most commonly prescribed drugs in clinical practice. Since the introduction of these potent acid-suppressing agents in the late 80s, they were listed in the Guinness Book of World Records as the most prescribed in human history. Yet, to be effective in inhibiting the proton pump enzyme (H+/K+ ATPase) in the parietal cells, these drugs should be taken ...

Hypersensitivity to lansoprazole with tolerance to other proton pump inhibitors: does cross-reactivity between proton pump inhibitors really exist?

Protection of human and animal subjects. The authors declare that the procedures followed were in accordance with the regulations of the responsible Clinical Research Ethics Committee and in accordance with those of the World Medical Association and the Helsinki Declaration. Confidentiality of data. The authors declare that they have followed the protocols of their work centre on the publicatio...

Proton Pump Inhibitors: Omeprazole

Oral Proton Pump Inhibitors

There is currently a lack of evidence to suggest superior clinical efficacy of one oral proton pump inhibitor over any other. Proton pump inhibitors display similar doseresponse relationships with similar potencies and efficacies at the equivalent dose. The decision to select one proton pump inhibitor over another is likely to be based on the agents’ licensed indication, patient tolerability an...

Intravenous proton pump inhibitors.

Intravenous (IV) administration of a proton pump inhibitor (PPI) is a faster way to achieve gastric acid suppression than oral administration of the same agent. Peak suppression after IV administration occurs within hours, compared with several days later after oral administration. Thus the IV route of administration offers a faster onset of gastric suppression, achievement of intragastric pH c...